Preparation of a chk1 inhibitor compound
AssigneesSentinel Oncology Limited, Pharmaengine, Inc.
InventorsStuart TRAVERS, Meriel MAJOR, Derek John LONDESBROUGH, Richard CHUBB
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Abstract
The invention provides a novel synthetic route for the preparation of the Chk-1 inhibitor compound: as well as novel process intermediates per se.
Claims15
A process for the preparation of a compound of formula (15):
- which process comprises reacting a compound of the formula (14):
- with hydrazine (NH2NH2).
A process for the preparation of a compound of the formula (14):
- which process comprises reacting a compound of formula (13):
- with acetonitrile (CH3CN) in the presence of a base.
A process for the preparation of a compound of the formula (13):
- which process comprises reacting a compound of formula (12):
- with a deoxyfluorination reagent.
A process for the preparation of a compound of the formula (12):
- which process comprises reacting a compound of formula (10):
- with a compound of formula (11):
- in the presence of a metallating agent, such as a Grignard reagent.
A process for the preparation of a compound of the formula (18):
- which process comprises reacting a compound of the formula (17):
- with an alkylsilyl halide or a sulphonic acid.
A process for the preparation of a compound of the formula (17):
- which process comprises the reaction of a compound of the formula (15)
- with a compound of the formula (16):
A compound of the formula (14):
A compound of the formula (13):
A compound of the formula (12):
An invention as defined in any one of Embodiments 1.1 to 1.7, 2.1 to 2.6, 3.1 to 3.6, 4.1 to 4.8, 5.1 to 5.5, 6.1 to 6.8 and 7.1 to 7.78 herein.
Dependencies are inferred from the claim text.