Back to results
US 2024/0285810 A1Published application
Development of a novel pet probe for targeted bacterial imaging
OwnerNalinikanth KOTAGIRI, Nabil SIDDIQUIinventors
Life of this patent
Estimating the term…
Abstract
A probe for positron emission tomography (PET) is disclosed. The probe is selected from the group consisting of yersini-abactin (Ybt) labeled with Copper-64; staphylopine (StP) labeled with Copper-64; yersiniabactin (Ybt) labeled with Zirconium-89; and staphylopine (StP) labeled with Zirconium-89.
Claims19
A probe for positron emission tomography (PET) selected from the group consisting of:
- yersiniabactin (Ybt) labeled with Copper-64;
- staphylopine (StP) labeled with Copper-64;
- yersiniabactin (Ybt) labeled with Zirconium-89;
- and
- staphylopine (StP) labeled with Zirconium-89.
2 more elements
A method of identifying a bacterial infection in vivo in a mammal, the method comprising the steps of:
- (a) administering a composition to the mammal comprising a positron emission tomography (PET) probe selected from the group consisting of:
- yersiniabactin (Ybt) labeled with Copper-64;
- staphylopine (StP) labeled with Copper-64;
- yersiniabactin (Ybt) labeled with Zirconium-89;
- and
- staphylopine (StP) labeled with Zirconium-89;
- (b) allowing the probe to accumulate in the mammal;
- and
- (c) observing the accumulated probe in the mammal using a positron emission tomography process;
- so that a concentration of the probe in the mammal is observed.
7 more elements
A method of selectively observing therapeutic bacteria in vivo in a mammal, the method comprising the steps of:
- (a) administering a composition to the mammal comprising therapeutic bacteria;
- (b) allowing the therapeutic bacteria to selectively accumulate in the mammal;
- (c) administering a composition to the mammal comprising a positron emission tomography (PET) probe selected from the group consisting of:
- yersiniabactin (Ybt) labeled with Copper-64;
- staphylopine (StP) labeled with Copper-64;
- yersiniabactin (Ybt) labeled with Zirconium-89;
- and
- staphylopine (StP) labeled with Zirconium-89;
- (d) allowing the probe to selectively accumulate in the mammal;
- and
- (e) observing the accumulated probe in the mammal using a positron emission tomography;
- so that the therapeutic bacteria is selectively observed in vivo in the mammal.
9 more elements
Dependencies are inferred from the claim text.