Ligand-binding nucleic acid complex
AssigneeRena Therapeutics Inc.
InventorsKoh TAKAGI, Hideki KIZAWA, Hiroshi OKAMOTO, Keiko KANEKO, Nobuyuki HUSE, Takashi OCHI
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AssigneeRena Therapeutics Inc.
InventorsKoh TAKAGI, Hideki KIZAWA, Hiroshi OKAMOTO, Keiko KANEKO, Nobuyuki HUSE, Takashi OCHI
Estimating the term…
The invention provides an S1P ligand-binding nucleic acid complex that is delivered to a target organ to regulate expression or editing of a target gene or a transcription or translation product thereof. The S1P ligand-binding nucleic acid complex includes a nucleic acid with an antisense oligonucleotide 12 to 30 nucleotides in length, and has a nucleic acid sequence complementary to a target transcription product, bound to a S1P ligand. The nucleic acid complex is useful for the treatment of a disease caused by such gene. The ligand-binding nucleic acid complex can be delivered to an organ, tissue, or cell in which the S1P receptor is expressed, such as the skeletal muscle, cardiac muscle, liver, kidney, lung, mammary gland, fat, podocyte, lymphocyte, or vascular endothelial cell.
A ligand-binding nucleic acid complex in which a nucleic acid molecule that regulates expression or editing of a target gene or a transcription or translation product thereof binds to a compound represented by a formula below or a pharmaceutically acceptable salt with or without a linker:
A ligand-binding nucleic acid complex, wherein a nucleic acid molecule that regulates expression or editing of a target gene or a transcription or translation product thereof binds to a ligand reacting with an S1P receptor.
Dependencies are inferred from the claim text.