Glyceric acid, glycerate, and composition thereof
AssigneesInner Mongolia Kingdomway Pharmaceutical Co., Ltd., Xiamen Kingdomway Group Company, Kingdomway Biotechnology (Jiangsu) Co., Ltd.
InventorsMing ZHEN, Mengjing LIU, Li WANG, Qiyue LIU, Biqin CHEN, Bingrong WANG, Dan LI, Yi WU, Guanghuang ZHAN
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Abstract
The present disclosure provides a crystalline form of calcium D-glycerate of formula and a method for preparing the crystalline form of calcium D-glycerate of formula (I). The crystalline form may be characterized by having X-ray powder diffraction pattern (XRPD) diffraction peaks (2θ degrees) at 12.9°±0.2°, 20.9°±0.2°, and 31.7°±0.2°.
Claims24
A crystalline form of calcium D-glycerate of formula (I)
- wherein the crystalline form is characterized by having X-ray powder diffraction pattern (XRPD) diffraction peaks (2θ degrees) at 12.9°±0.2°, 20.9°±0.2°, and 31.7°±0.2°.
8-9. (canceled)
11-12. (canceled)
A crystalline form of calcium D-glycerate of formula (II)
- wherein the crystalline form is characterized by having X-ray powder diffraction pattern (XRPD) diffraction peaks (2θ degrees) at 15.4°±0.2°, 17.0°±0.2°, and 27.1°±0.2°.
19-21. (canceled)
A method for preparing an amorphous form of calcium glycerate of formula (III)
- the method comprising:
- stirring a crystalline form of calcium glycerate with a solvent at a first temperature for a first time period to form a suspension solution;
- maintaining the first temperature and filtering the suspension solution to form a supersaturated solution;
- stirring the supersaturated solution at a stirring rate, and cooling the supersaturated solution at a cooling rate;
- after cooling the supersaturated solution to a second temperature, maintaining the second temperature, aging the supersaturated solution for a second time period, and filtering the supersaturated solution;
- and
- drying the filtered product for a third time period at a pressure and a third temperature to obtain the amorphous form of calcium glycerate.
28-44. (canceled)
Dependencies are inferred from the claim text.