Large scale purification of antibodies
AssigneeAriel Scientific Innovations Ltd.
InventorGuy PATCHORNIK
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Abstract
A method of isolating an antibody is disclosed. The method comprises contacting an aggregate comprising a hydrophobic chelator, at least one non-ionic detergent, metal ions and a non-detergent hydrophobic agent with a liquid sample comprising the antibody under conditions that allow partitioning of the antibody into the aggregate, thereby isolating the antibody. Kits for isolating antibodies are also disclosed.
Claims28
A method of isolating an antibody, the method comprising contacting an aggregate comprising a hydrophobic chelator, at least one non-ionic detergent, metal ions and a non-detergent hydrophobic agent with a liquid sample comprising the antibody under conditions that allow partitioning of the antibody into said aggregate, thereby isolating the antibody.
A method of isolating an antibody, the method comprising contacting an aggregate comprising a hydrophobic chelator which has been solubilized in a non-volatile, water miscible organic solvent, at least one non-ionic detergent and metal ions with a liquid sample comprising the antibody under conditions that allow partitioning of the antibody into said aggregate, thereby isolating the antibody.
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Dependencies are inferred from the claim text.