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AssigneeNational Institutes of Health Nhlbi
InventorsThomas Theis, Mustapha Abdulmojeed, Sören Lehmkuhl, Patrick TomHon, Iuliia Mandzhieva, Eduard Y. Chekmenev, Isaiah Adelabu, Mohammad Kabir, Shiraz Nantogma, Jessica Ettedgui, Rolf Eric Swenson, Boyd Goodson
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In one aspect, the disclosure relates to hyperpolarized target molecules and contrast agents comprising the same, methods of making the same, and methods of imaging using same. In a further aspect, imaging performed using the hyperpolarized target molecules and contrast agent can enable real time monitoring and diagnosis of diseases including various cancers and metabolic disorders. The methods are cryogen-free and inexpensive and can be performed in a short time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
A method for hyperpolarization of a target molecule, the method comprising:
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-14. (canceled)
The method of claim 13, wherein the low temperature is about −50° C. and the high temperature is about 100° C.
The method of claim 13, wherein the low temperature is about −10° C. and the high temperature is about 25° C.
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-56. (canceled)
A contrast agent comprising the hyperpolarized target molecule of claim 56.
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Dependencies are inferred from the claim text.