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US 2024/0254559 A1Published application
Genomic stability profiling
AssigneeCaris MPI, Inc.
InventorsDavid Spetzler, Nianqing Xiao
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Abstract
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for the disease, such as treatments that provide potential benefit or potential lack of benefit for the disease. Molecular profiling can include biomarkers for immune checkpoint therapy, including microsatellite instability, tumor mutational burden, mismatch repair, and expression of checkpoint proteins such as PD-L1.
Claims22
(canceled)
A method of determining microsatellite instability (MSI) in a biological sample of a patient, the method comprising:
- (a) obtaining a nucleic acid sequence for each of a plurality of microsatellite loci from the biological sample, thereby obtaining nucleic acid sequences;
- (b) determining a number of altered microsatellite loci based on the nucleic acid sequences obtained in step (a);
- (c) comparing the number of altered microsatellite loci determined in step (b) to a threshold number that is selected based on a patient characteristic of the patient;
- (d) identifying the biological sample as MSI-high when the number of altered microsatellite loci determined in step (b) is greater than or equal to the threshold number;
- and
- (e) administer immunotherapy to the patient based on the biological sample being MSI-high.
3 more elements
Dependencies are inferred from the claim text.