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US 2024/0254536 A1Published application
Antibiotic pin array and uses thereof
AssigneeDrugArray, Inc.
InventorsDayu TENG, Jieying LI
Life of this patent
Estimating the term…
Abstract
Described herein are reagent loading devices configured to simultaneously deliver one or more test agents (e.g., antibiotics) to a sample such as a bacterial culture without having to individually deliver the test agents. These devices allow high throughput parallel processes without repetitive pipetting or liquid handling robotics. Also described herein are kits and systems for chemical or biological assays.
Claims28
A pin array device for chemical or biological assays, comprising:
- a plurality of first pins comprising a proximal end and a distal end, wherein the first pins comprise closed tips at the distal end of the pins;
- a plate having a proximal surface and a distal surface;
- wherein the plurality of first pins are integral to the plate and are on the distal surface of the plate, wherein the plurality of first pins form an array.
A method of performing a chemical or biological assay, comprising:
- i) preparing a target cell culture (e.g. a bacteria) on a solid culture media in a dish;
- ii) applying one or more compositions comprising an agent (e.g. an antibiotic drug) to tips of a plurality of first pins, wherein the first pins are integral to a plate that comprises a proximal surface and a distal surface, wherein the first pins are on the distal surface of the plate, and wherein the plurality of first pins form an array;
- iii) stamping the tips of the plurality of first pins to the target cell culture, wherein the effects of the agents on the target cell culture are analyzed.
A method of performing a chemical or biological assay, comprising:
- i) preparing a target cell culture (e.g. a bacteria) on a solid culture media in a dish;
- ii) contacting the tips of a plurality of first pins pre-loaded with one or more compositions comprising an agent (e.g. an antibiotic drug) with the target cell culture, wherein the first pins are integral to a plate that comprises a proximal surface and a distal surface, wherein the first pins are on the distal surface of the plate, and wherein the plurality of first pins form an array,
- iii) analyzing the effects of the agents on the target cell culture.
Dependencies are inferred from the claim text.