Method for producing antibody population

Abstract

Provided is a method for producing an antibody population and, specifically, to an antibody population of desired quality that is produced by culturing recombinant cells expressing antibodies under elaborately controlled culturing conditions such as pH and culture temperature, and a method for effectively producing an antibody population of high quality with excellent biological activity. The present method can effectively prepare an antibody population having desired proportions of main active antibodies and isomeric antibodies and an antibody population having a desired glycan structure by adjusting pH, culture temperature, and/or lactic acid supply. In addition, the present method can produce high-quality antibodies having excellent biological activity capable of reaching desired therapeutic efficacy when therapeutic monoclonal antibodies are generated. In particular, with respect to the manufacture of biosimilar drugs, it is possible to effectively manufacture antibodies of the same or very similar quality to the original drug by elaborately adjusting the culture conditions.

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