Modulation of coasy expression
AssigneesEmpirico Inc., Ionis Pharmaceuticals, Inc.
InventorsOmri GOTTESMAN, Shannon BRUSE, Brian CAJES, David JAKUBOSKY, Sarah KLEINSTEIN, John VEKICH, Richard LEE, Susan F. MURRAY
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Abstract
Provided herein are specific inhibitors, compositions, methods and uses for reducing expression of COASY in a cell or individual. Such specific inhibitors, compositions, and methods are useful to treat a liver disease or disorder, including but not limited to NASH, in a subject.
Claims88
A method of treating a liver disease or disorder in a subject having a liver disease or disorder, comprising administering a COASY-specific inhibitor to the subject, thereby treating the liver disease or disorder in the subject.
A method comprising administering a COASY-specific inhibitor to a subject.
A method comprising contacting a cell with a COASY-specific inhibitor.
A method of inhibiting expression or activity of COASY in a cell comprising contacting the cell with a COASY-specific inhibitor, thereby inhibiting expression or activity of COASY in the cell.
Use of a COASY-specific inhibitor for the manufacture or preparation of a medicament for treating a liver disease or disorder.
Use of a COASY-specific inhibitor for the treatment of a liver disease or disorder.
The use of any of claim 51-81, wherein the COASY-specific inhibitor is administered parenterally.
Dependencies are inferred from the claim text.