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US 2024/0254437 A1Published application
Methods and compositions for the production of oligodendrocyte progenitor cells
AssigneePresident and Fellows of Harvard College
InventorsParastoo Khoshakhlagh, Hon Man Alex Ng, George M. Church
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Abstract
Provided herein are pluripotent stem cells comprising particular combinations of transcription factor for the production of oligodendrocyte progenitor cells (OPCs). Also provided herein are methods of producing the pluripotent stem cells and methods of using the pluripotent stem cells to produce (OPCs) and oligodendrocytes.
Claims21
-68. (canceled)
A method comprising:
- introducing into pluripotent stem cells at least four transcription factors selected from (a) oligodendrocyte 2 (OLIG2), (b) SRY-box 9 (SOX9), (c) NKX homeobox 6.1 (NKX6.1), (d) NKX homeobox 6.2 (NKX6.2), and (e) octamer-binding 4 (OCT4),
- culturing the pluripotent stem cells;
- and
- inducing the pluripotent stem cells to produce a population of cells comprising oligodendrocyte progenitor cells (OPCs), wherein the pluripotent stem cells produce the population of cells comprising OPCs within 30 days of the inducing.
1 more element
Dependencies are inferred from the claim text.