Anti-cd30l antibodies and uses thereof
AssigneesPrometheus Biosciences, Inc., Dr. Falk Pharma GmbH
InventorsJessie-Farah FECTEAU, Mark RENSHAW, Johan FRANSSON, Olivier LAURENT, Burton BARNETT
Life of this patent
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Abstract
Described herein are anti-CD30L antibodies and pharmaceutical compositions for the treatment of autoimmune diseases and disorders such inflammatory bowel disease (IBD), including Crohn's Disease (CD) and ulcerative colitis (UC).
Claims92
An antibody or antigen binding fragment thereof that binds CD30L, wherein the antibody or antigen binding fragment thereof comprises:
- (a) a CDR-H1 comprising the amino acid sequence set forth in any one of SEQ ID NOs:
- 100-139, 220-234, 465-489, 628-641, and 712-723;
- (b) a CDR-H2 comprising the amino acid sequence set forth in any one of SEQ ID NOs:
- 140-179, 235-249, 490-499, 513-527, 642-655, and 724-735;
- (c) a CDR-H3 comprising the amino acid sequence set forth in any one of SEQ Id NOs:
- 180-219, 250-264, 528-552, 656-669, and 736-743;
- (d) a CDR-L1 comprising the amino acid sequence set forth in any one of SEQ ID NOs:
- 300-339, 420-434, 553-577, 670-683, and 744-751;
- (d) CDR-L2 comprising the amino acid sequence set forth in any one of SEQ ID NOs:
- 340-379, 435-449, 578-602, 684-697, and 752-759;
- and/or
- (e) a CDR-L3 comprising the amino acid sequence set forth in any one of SEQ ID NOs:
- 380-419, 450-464, 603-627, 698-711, and 760-765.
An antibody or antigen binding fragment thereof that binds CD30L, wherein the antibody or antigen binding fragment thereof binds to an epitope comprising one or more amino acids in CD30L selected from the group consisting of K16, S21, R30, K48, R63, and Y64, wherein the amino acids are numbered according to the amino acid sequence of CD30L as set forth in SEQ ID NO:34.
An antibody or antigen binding fragment thereof that binds CD30L, wherein the antibody or antigen binding fragment thereof binds to an epitope comprising K16 in CD30L, wherein the amino acids are numbered according to the amino acid sequence of CD30L as set forth in SEQ ID NO:34.
Dependencies are inferred from the claim text.