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US 2024/0254196 A1Published application
Heterodimeric fc fusion protein, and composition, use, and method related to same
AssigneeMedytox Inc.
InventorsEun Shik CHOI, Hyun Kyu PARK
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Abstract
Provided are heterodimeric Fc fusion proteins that are not only fast, simple, and efficient to purify, but also exhibit desirable therapeutic properties, such as increased FcRn binding capacity or increased FcγR binding capacity, and compositions, uses, methods related thereto.
Claims37
A heterodimeric Fc fusion protein, comprising:
- i) a first polypeptide including a first target protein, a first linker, and a first Fc region of an immunoglobulin in the N-terminus to C-terminus direction;
- and
- ii) a second polypeptide including a second target protein, a second linker, and a second Fc region of an immunoglobulin in the N-terminus to C-terminus direction, wherein
- the first target protein and the second target protein are different proteins from each other, and the first linker and the second linker are a κ light chain constant region (CLκ) or a variant thereof and a λ light chain constant region (CLλ) or a variant thereof, respectively.
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Dependencies are inferred from the claim text.