Ultrahigh-affinity small protein targeting pd-l1 and use
AssigneeChinese Pla General Hospital
InventorsLei ZHAO, Yi HU, Fan ZHANG
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Abstract
Provided are a class of ultrahigh-affinity small proteins targeting PD-L1 and the use. A class of binding proteins can target PD-L1 and has an ultrahigh affinity. The proteins can competitively bind to wild-type PD-1. The affinity to PD-L1 is much higher than the affinity of the wild-type PD-1 to PD-L1. A fusion protein contains the ultrahigh-affinity protein targeting PD-L1 is also provided.
Claims19
A small protein targeting PD-L1, wherein the small protein specifically targets PD-L1 with an ultrahigh affinity, and competes with wild-type PD-1 for binding to PD-L1 and effectively blocks binding of PD-1 to PD-L1;
- wherein, the small protein consists of a peptide chain which mainly forms three α-helix secondary structures;
- and
- the amino acid sequence of the small protein is shown in SEQ ID NOs:
- 1, 3, 5 or 7.
13-14. (canceled)
A small protein targeting PD-L1, wherein the small protein specifically targets PD-L1 with an ultrahigh affinity, and competes with wild-type PD-1 for binding to PD-L1 and effectively blocks binding of PD-1 to PD-L1;
- wherein, the small protein consists of a peptide chain which mainly forms three α-helix secondary structures;
- and the amino acid sequence of the small protein is shown in SEQ ID NO:
- 1.
17-19. (canceled)
Dependencies are inferred from the claim text.