Macrolide compounds

A compound having the formula:

• or a pharmaceutically acceptable salt thereof,
• wherein
• R1 is selected from H, OH, C1-8alkyl.
• R2 is selected from H, OH, C1-8alkyl.
• R3 is selected from H, OH, C1-8alkyl.
• R4 is selected from H, OH, C1-8alkyl.
• Q1 is a group having the formula:
• wherein
• R2a is selected from —R2a*, —OR2a*, OP(O)(OR2a*)2, OP(O)(OR2a*)(N(R2a*)2, —N(R2a*)2, —N(R2a*)3, —C(O)R2a*, —C(O)OR2a*, —OC(O)R2a*, —OC(O)OR2a*, —NR2a*C(O)R2a*, —C(O)N(R2a*)2, NR2a*C(O)OR2a*, —OC(O)N(R2a*)2, —NR2a*C(O)N(R2a*)2;
• —Cl, —F, —Br, —I, —NO2, —CN, —N3, —(OCH2CH2)m—OH;
• R2a* is in each case independently selected from H, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, aryl, C3-10cyclolkyl, C3-10cycloalkenyl, C7-10cycloalkynyl, aryl, C1-10heterocycyl, C1-10heteroaryl;
• wherein each R2a* may be substituted one or more times by —OH, —COOH, —, —PPh3, —CH2NEt3, —CH2NMe3, —NHC(═NH)NH2, a rhodamine dye, a bisquinolinium, —NH2, —Cl, —F, —Br, —I, —NO2, —CN, —N3, PO(OH)2, —(OCH2CH2)m—OH;
• C1-8heterocycyl, aryl, —OC1-8heterocycyl, or C1-8alkoxy,
• wherein any two or more of R2a* may together form a ring;
• R3a is selected from —R3a*, —OR3a*, OP(O)(OR3a*)2, OP(O)(OR3a*)(N(R3a*)2, —N(R3a*)2, —N(R3a*)3—C(O)R3a*, —C(O)OR3a*, —OC(O)R3a*, —OC(O)OR3a*, —NR3a*C(O)R3a*, —C(O)N(R3a*)2, NR3a*C(O)OR3a*, —OC(O)N(R3a*)2, —NR3a*C(O)N(R3a*)2;
• —Cl, —F, —Br, —I, —NO2, —CN, —N3, —(OCH2CH2)m—OH;
• R3a* is in each case independently selected from H, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, aryl, C3-10cyclolkyl, C3-10cycloalkenyl, C7-10cycloalkynyl, aryl, C1-10heterocycyl, C1-10heteroaryl;
• wherein each R3a* may be substituted one or more times by —OH, —COOH, —PPh3, —CH2NEt3, —CH2NMe3, —NHC(═NH)NH2, a rhodamine dye, a bisquinolinium, —NH2, —Cl, —F, —Br, —I, —NO2, —CN, —N3, PO(OH)2, —(OCH2CH2)m—OH;
• C1-8heterocycyl, aryl, —OC1-8heterocycyl, or C1-8alkoxy,
• wherein any two or more of R3a* may together form a ring;
• R4a is selected from —R4a*, —OR4a*, OP(O)(OR4a*)2, OP(O)(OR4a*)(N(R4a*)2, —N(R4a*)2, —N(R4a*)3, —C(O)R4a*, —C(O)OR4a*, —OC(O)R4a*, —OC(O)OR4a*, —NR4a*C(O)R4a*, —C(O)N(R4a*)2, NR4a*C(O)OR4a*, —OC(O)N(R4a*)2, —NR4a*C(O)N(R4a*)2;
• —Cl, —F, —Br, —I, —NO2, —CN, —N3, —(OCH2CH2)m—OH;
• R4a* is in each case independently selected from H, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, aryl, C3-10cyclolkyl, C3-10cycloalkenyl, C7-10cycloalkynyl, aryl, C1-10heterocycyl, C1-10heteroaryl;
• wherein each R4a* may be substituted one or more times by —OH, —COOH, —PPh3, —CH2NEt3, —CH2NMe3, —NHC(═NH)NH2, a rhodamine dye, a bisquinolinium, —NH2, —Cl, —F, —Br, —I, —NO2, —CN, —N3, PO(OH)2, —(OCH2CH2)m—OH;
• C1-8heterocycyl, aryl, —OC1-8heterocycyl, or C1-8alkoxy;
• wherein any two or more of R4a* may together form a ring;
• R5a is selected from —R5a*, —OR5a*, OP(O)(OR5a*)2, OP(O)(OR5a*)(N(R5a*)2, —N(R5a*)2, —N(R5a*)3, —C(O)R5a*, —C(O)OR5a*, —OC(O)R5a*, —OC(O)OR5a*, —NR5a*C(O)R5a*, —C(O)N(R5a*)2, NR5a*C(O)OR5a*, —OC(O)N(R5a*)2, —NR5a*C(O)N(R5a*)2;
• —Cl, —F, —Br, —I, —NO2, —CN, —N3, —(OCH2CH2)m—OH;
• R5a* is in each case independently selected from H, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, aryl, C3-10cyclolkyl, C3-10cycloalkenyl, C7-10cycloalkynyl, aryl, C1-10heterocycyl, C1-10heteroaryl;
• wherein each R5a* may be substituted one or more times by —OH, —COOH, —PPh3, —CH2NEt3, —CH2NMe3, —NHC(═NH)NH2, a rhodamine dye, a bisquinolinium, —NH2, —Cl, —F, —Br, —I, —NO2, —CN, —N3, PO(OH)2, —(OCH2CH2)m—OH;
• C1-8heterocycyl, aryl, —OC1-8heterocycyl, or C1-8alkoxy;
• wherein Rp is in each case selected from H, C1-10alkyl, and aryl;
• wherein any two or more of R5a* may together form a ring;
• wherein any two of more of R2a, R3a, R4a, and R5a may together form a ring;
• Q2 is a group having the formula:
• wherein:
• R1b is selected from H, OH, C1-8alkyl, and OC1-8alkyl;
• R2b is selected from —R2b*, —OR2b*, OP(O)(OR2b*)2, OP(O)(OR2b*)(N(R2b*)2, —N(R2b*)2, —N(R2b*)3, —C(O)R2b*, —C(O)OR2b*, —OC(O)R2b*, —OC(O)OR2b*, —NR2b*C(O)R2b*, —C(O)N(R2b*)2, NR2b*C(O)OR2b*, —OC(O)N(R2b*)2, —NR2b*C(O)N(R2b*)2;
• —Cl, —F, —Br, —I, —NO2, —CN, —N3, —(OCH2CH2)m—OH;
• R2b* is in each case independently selected from H, C1-8alkyl, C1-8alkenyl, C1-10alkynyl, aryl, C3-8cyclolkyl, C3-8cycloalkenyl, C7-10cycloalkynyl, aryl, C1-8heterocycyl, C3-8heteroaryl;
• wherein each R2b* may be substituted one or more times by —OH, —COOH, —PPh3, —CH2NEt3, —CH2NMe3, —NHC(═NH)NH2, a rhodamine dye, a bisquinolinium, —NH2, —Cl, —F, —Br, —I, —NO2, —CN, —N3, PO(OH)2, —(OCH2CH2)m—OH;
• C1-8heterocycyl, aryl, —OC1-8heterocycyl, or C1-8alkoxy,
• wherein any two or more of R2b* may together form a ring;
• R3b is selected from H or a group having the formula:
• wherein
• R3d is selected from H and CH3;
• and
• R4d is selected from H and a group having the formula:
• wherein m is in each case selected from 1-100;
• with the proviso that when all of R2a, R3a, and R4a are OH, R2b is not CH2CH2CH2OCH3.