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US 2024/0254134 A1Published application
Agelastatin a derivatives and related methods
AssigneeBaylor University
InventorsDaniel Romo, Kevin Shuford, Haoran Xue, Emvia Calixte, Kenneth Hull, Morgan Jouanneau
Life of this patent
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Abstract
Agelastatin compounds, methods for making agelastatin compounds, and methods for using agelastatin compounds.
Claims11
A compound of formula (I):
- or a stereoisomer, racemate, or a pharmaceutically acceptable salt thereof,
- wherein
- R1 is selected from the group consisting of H, F, Cl, and Br;
- R2 is selected from the group consisting of H, F, Cl, and Br;
- R3 is selected from the group consisting of Br, CF3, SF5, SO2CF3, SO2CH3, CN, and NO2;
- R4 is selected from the group consisting of H, OH, F, Cl, Br, and CN;
- and
- R5 is H.
5 more elements
A method for making a compound of formula (I), comprising converting a compound of formula (A) to a compound of formula (I) via a compound of formula (B):
- wherein the compound of formula (A) is reacted with
- to provide amide (a):
- converting amide (a) to the compound of formula (B) followed by ring closure to provide 7-hydroxy compound (b):
- and
- converting 7-hydroxy compound (b) to the compound of formula (I) by treatment aqueous acid,
- wherein
- P is an alcohol protecting group;
- R is a methyl group;
- R1 is selected from the group consisting of H, F, Cl, and Br;
- R2 is selected from the group consisting of H, F, Cl, and Br;
- R3 is selected from the group consisting of Br, CF3, SF5, SO2CF3, SO2CH3, CN, and NO2;
- R4 is selected from the group consisting of H, OH, F, Cl, Br, and CN;
- and
- R5 is H.
11 more elements
Dependencies are inferred from the claim text.