A broadly protective prophylactic vaccine against pseudomonas aeruginosa
AssigneesUniversity of Kansas, University of Maryland, Baltimore
InventorsWendy L. PICKING, William D. PICKING, Robert K. ERNST
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Abstract
Disclosed are compositions comprising a fusion polypeptide comprising i) a fusion of a needle tip protein or an antigenic fragment thereof and/or a translocator protein or an antigenic fragment thereof from a Type III secretion system (T3SS) of a Gram negative bacteria and ii) the A1 subunit of the labile toxin (LTA1) from enterotoxigenic Escherichia coli or cholera toxin, and methods of their use.
Claims20
A fusion polypeptide comprising i) a fusion of a needle tip protein or an antigenic fragment thereof and/or a translocator protein or an antigenic fragment thereof from a Type III secretion system (T3SS) of a Gram negative bacteria and ii) the A1 subunit of the labile toxin (LTA1) from enterotoxigenic Escherichia coli or cholera toxin.
A method treating an opportunistic infection in a subject with cystic fibrosis comprising administering to the subject a therapeutically effective amount of a composition comprising a fusion polypeptide comprising i) a fusion of a needle tip protein or an antigenic fragment thereof and/or a translocator protein or an antigenic fragment thereof from a Type III secretion system (T3SS) of Pseudomonas aeruginosa or Burkholderia cepacia and ii) the A1 subunit of the labile toxin (LTA1) from enterotoxigenic Escherichia coli or cholera toxin.
Dependencies are inferred from the claim text.