Optimizing analyte sensor calibration

A continuous glucose monitoring system, comprising:

• a data processing unit having:
• a data processing unit non-transitory memory, and
• at least one data processing unit processor communicatively coupled to the data processing unit non-transitory memory,
• a glucose sensor having a first portion configured to be positioned through a user's skin and in contact with an interstitial fluid of the user for in vivo detection of glucose and a second portion configured to remain above the user's skin and coupled to the data processing unit;
• a first receiver communicatively coupled to the data processing unit via a first Bluetooth communication link and including:
• a first receiver non-transitory memory,
• at least one first receiver processor coupled to the first receiver non-transitory memory, and
• a first receiver output device;
• a watch receiver communicatively coupled to the data processing unit via a second Bluetooth communication link, and including:
• a watch receiver non-transitory memory, and
• at least one watch receiver processor coupled to the watch receiver non-transitory memory,
• wherein the watch receiver is configured to:
• receive, via the watch, a current blood glucose measurement of the user determined based on a finger prick test;
• provide a prompt to the user to accept or decline execution of a calibration routine using the current blood glucose measurement;
• upon receiving an acceptance from the user to the prompt, confirm:
• (1) that the current blood glucose measurement is within a predetermined glucose-value range, and
• (2) that a rate of change of a glucose level detected by the glucose sensor is within a predetermined rate-of-change range;
• upon confirming (1) and (2) initiate the calibration routine and calibrate the glucose sensor using the current blood glucose measurement;
• wherein if a decline to the prompt is received from the user, the watch receiver is further configured to store the current blood glucose measurement.