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US 2024/0246924 A1Published application
Substituted ethylamine fused heterocyclic mescaline derivatives
AssigneeEnveric Biosciences Canada Inc.
InventorsKaveh Matinkhoo, David James Press, Jessica Lee, Charlie Cai, Jillian M. Hagel, Peter J. Facchini
Life of this patent
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Abstract
Disclosed are novel fused mescaline derivative compounds, notably substituted ethylamine fused heterocyclic mescaline derivatives, including substituted ethylamine fused dioxolane mescaline derivatives, and pharmaceutical and recreational drug formulations containing the same. Methods of making and using these compounds are also disclosed.
Claims30
A compound having chemical formula (I) or (II):
- wherein, in chemical formula (I) or (II):
- X1, X2, and X3 are independently selected from a hydrogen atom, O-alkyl, acyl, N-(alkyl)2, N-(alkyl)(H), OH, a halogen, or NH2;
- X4 is an alkylene group or substituted alkylene group;
- R1′ and R1″ are independently or simultaneously an alkyl group, or a hydrogen atom, wherein at least one of R1′ and R1″ is hydrogen, or R1′ and R1″ are joined together to form an oxo group (C═O) or a cycloalkyl group;
- or R1″ is joined together with R1b, together with the carbon atom to which R1″ is attached and the nitrogen atom to which R1b is attached, to form an optionally substituted saturated or unsaturated 3-10-membered heterocyclic ring, and when the heterocyclic ring is unsaturated, R1′ and R1a are optionally absent;
- and
- R2 is an alkyl group, O-alkyl group, hydroxy group, or a hydrogen atom;
- and at least one of R1′, R1″ and R2 is a substituent other than a hydrogen atom,
- and when R1″ is not joined together with R1b, R1a and R1b are each independently selected from an alkyl group, a hydroxylalkyl group, an optionally substituted alkyl-aryl group, or a hydrogen atom, or R1a and R1b are joined together, along with the nitrogen atom to which they are attached, to form a 3-10-membered optionally substituted heterocyclic ring, or NR1aR1b is a nitro group;
- and
- when R1′ and R1″ are joined to form an oxo group, R2 is an alkyl group, O-alkyl group, or hydroxy group.
8 more elements
Dependencies are inferred from the claim text.