Non-invasive detection and differentiation of sepsis

An apparatus, comprising:

• a processor;
• and
• a non-transitory computer readable medium in communication with the processor, the non-transitory computer readable medium having encoded thereon a set of instructions executable by the processor to:
• obtain, with one or more sensors disposed in a sensor device, physiological data of a user continuously over a first time period, the physiological data comprising non-invasively obtained waveforms of physiological data;
• determine based on the physiological data, a hemodynamic parameter of the patient over the first time period, wherein the hemodynamic parameter is a patient-specific indication of the patient's proximity to hemodynamic decompensation at a given time, wherein the hemodynamic parameter is a numerical value indicating a relationship between an intravascular volume loss of a patient at the given time and an intravascular volume loss at hemodynamic decompensation of the patient, wherein determining the hemodynamic parameter of the patient comprises:
• applying a hemodynamic model to the physiological data, the hemodynamic model relating the physiological data to the hemodynamic parameter, wherein the hemodynamic model comprises a plurality waveforms of reference data;
• comparing one or more waveforms of the physiological data of the patient to the each of the plurality of waveforms of reference data, each of the plurality of waveforms of reference data corresponding to a respective value of the hemodynamic parameter;
• determining the hemodynamic parameter of the patient based on the comparison to each of the plurality of waveforms of reference data;
• determine based on the hemodynamic parameter of the patient over the first time period, whether the patient is septic, wherein determining whether the patient is septic further comprises:
• applying a sepsis model to the hemodynamic parameter of the patient over the first time period, wherein the hemodynamic parameter over the first time period is a waveform of the hemodynamic parameter of the patient, the sepsis model relating waveforms of the hemodynamic parameter to a sepsis value representing whether the patient is septic, wherein sepsis model comprises a plurality of reference waveforms of the hemodynamic parameter;
• comparing the waveform of the hemodynamic parameter of the patient over the first time period to each of the plurality of reference waveforms of the hemodynamic parameter, each of the plurality of reference waveforms of the hemodynamic parameter corresponding to a respective sepsis value;
• and
• determining whether the patient is septic based on the sepsis value of the patient;
• and
• display, on a display screen of a user device, at least one of the hemodynamic parameter of the patient and a determination of whether the patient is septic.

A system, comprising:

• one or more sensors configured to obtain physiological data from a patient, the physiological data comprising non-invasively obtained waveforms of physiological data;
• a computer system in communication with the one or more sensors, the computer system comprising:
• a processor;
• and
• a non-transitory computer readable medium in communication with the processor, the non-transitory computer readable medium having encoded thereon a set of instructions executable by the processor to:
• obtain, with one or more sensors disposed in a sensor device, physiological data of a user continuously over a first time period, the physiological data comprising non-invasively obtained waveforms of physiological data;
• a hemodynamic parameter of the patient over the first time period, wherein the hemodynamic parameter is a patient-specific indication of the patient's proximity to hemodynamic decompensation at a given time, wherein the hemodynamic parameter is a numerical value indicating a relationship between an intravascular volume loss of a patient at the given time and an intravascular volume loss at hemodynamic decompensation of the patient, wherein determining the hemodynamic parameter of the patient comprises:
• applying a hemodynamic model to the physiological data, the hemodynamic model relating the physiological data to a value of the hemodynamic parameter, wherein the hemodynamic model comprises a plurality waveforms of reference data;
• comparing one or more waveforms of the physiological data of the patient to the each of the plurality of waveforms of reference data, each of the plurality of waveforms of reference data corresponding to a respective value of the hemodynamic parameter;
• determining the hemodynamic parameter of the patient based on the comparison to each of the plurality of waveforms of reference data;
• determine based on the hemodynamic parameter of the patient over the first time period, whether the patient is septic, wherein determining whether the patient is septic further comprises:
• applying a sepsis model to the hemodynamic parameter of the patient over the first time period, wherein the hemodynamic parameter over the first time period is a waveform of the hemodynamic parameter of the patient, the sepsis model relating waveforms of the hemodynamic parameter to a sepsis value representing whether the patient is septic, wherein sepsis model comprises a plurality of reference waveforms of the hemodynamic parameter;
• comparing the waveform of the hemodynamic parameter of the patient over the first time period to each of the plurality of reference waveforms of the hemodynamic parameter, each of the plurality of reference waveforms of the hemodynamic parameter corresponding to a respective sepsis value;
• and
• determining whether the patient is septic based on the sepsis value of the patient;
• and
• display, on a display screen of a user device, at least one of the hemodynamic parameter of the patient and a determination of whether the patient is septic.