Transcription factor
AssigneeSun Pharmaceutical Industries (Australia) Pty Ltd
InventorsIan Graham, Thilo Winzer
Life of this patent
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Abstract
The disclosure relates to transcription cassettes and vectors comprising a nucleotide sequence encoding a transcription factor; plants, plant cells, plant cell cultures and seeds that are genetically engineered to include a recombinant copy or copies of the nucleic acid encoding said transcription factor; and processes for the extraction of benzylisoquinoline alkaloids from the genetically engineered plants.
Claims29
An expression cassette adapted for plant expression comprising a nucleic acid molecule selected from:
- i) a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID NO:
- 1;
- ii) a nucleic acid molecule the complementary strand of which hybridizes under stringent hybridization conditions to the sequence in SEQ ID NO:
- 1 wherein said nucleic acid molecule encodes a transcription factor;
- iii) a nucleic acid molecule comprising a nucleotide sequence that encodes a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:
- 2;
- iv) a nucleic acid molecule comprising a nucleotide sequence that encodes a polypeptide comprising an amino acid sequence wherein said amino acid sequence is modified by addition deletion or substitution of at least one amino acid residue as represented in i) ii) or iii) above and wherein said polypeptide is a transcription factor and said transcription factor controls transcription of said one or more genes involved in the synthesis of benzylisoquinoline alkaloids.
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A Papaver plant, or plant part thereof, comprising a gene encoding a transcription factor comprising a nucleotide sequence set forth in SEQ ID NO:
- 1, or a polymorphic sequence variant of SEQ ID NO:
- 1 wherein said nucleotide sequence is modified wherein the modified nucleotide sequence encodes a transcription factor with reduced or undetectable transcription factor activity.
Dependencies are inferred from the claim text.