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AssigneeNeuracle Science Co., Ltd.
InventorsJae Young SEONG, Youngjoo BYUN, Hoyun KWAK, Sitaek OH, Min-Hyeok LEE, Yongwoo JEONG, Nui HA, Eun-Ho CHO, Suhyun LEE, Sang-Myeong LEE, Yerim LEE, Eun Bee CHO, Jae Keun LEE, Han-Byul KIM, Soon-gu KWON
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The present disclosure provides mimic molecules that are capable of specifically targeting a FAM19A5 protein, and thereby, inhibiting, reducing, and/or dissociating the interaction between members of the LRRC4 protein family and the FAM19A5 protein. The present disclosure also provides methods for promoting neurite outgrowth, by administering a mimic molecule described herein.
A Leucine Rich Repeat Containing 4 (“LRRC4”) family mimic molecule that is capable of inhibiting, reducing, and/or dissociating an interaction between a Family with Sequence Similarity 19, Member A5 (“FAM19A5”) protein and a member of a LRRC4 protein family.
A LRRC4 family mimic molecule comprising a polypeptide, which comprises an amino sequence having the following formula (from N-terminus to C-terminus):
A LRRC4 family mimic molecule comprising a polypeptide, which comprises an amino acid sequence having the following formula:
A LRRC4 family mimic molecule comprising a polypeptide, which comprises an amino acid sequence having at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 95%, or at least about 99% sequence identity to the amino acid sequence set forth in SEQ ID NO:
A LRRC4 family mimic molecule comprising a polypeptide, which comprises an amino acid sequence that is at least about 70%, at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or about 99% identical to the amino acid sequence set forth in SEQ ID NO:
A method of increasing a neurite outgrowth and/or synapse formation in neurons, comprising contacting a neuron with a Leucine Rich Repeat Containing 4 (“LRRC4”) family mimic molecule, wherein the LRRC4 family mimic molecule is capable of inhibiting, reducing, and/or dissociating an interaction between a Family with Sequence Similarity 19, Member A5 (“FAM19A5”) protein and a member of a LRRC4 protein family, and wherein the LRRC4 family mimic molecule is a small molecule selected from:
A method of inhibiting or decreasing a formation of a complex between a FAM19A5 protein and a member of the LRRC4 protein family in a subject in need thereof, comprising administering to the subject a Leucine Rich Repeat Containing 4 (“LRRC4”) family mimic molecule, wherein the LRRC4 family mimic molecule is capable of inhibiting, reducing, and/or dissociating an interaction between a Family with Sequence Similarity 19, Member A5 (“FAM19A5”) protein and a member of a LRRC4 protein family, and wherein the LRRC4 family mimic molecule is a small molecule selected from:
A method of treating a disease or condition in a subject in need thereof, comprising administering to the subject a Leucine Rich Repeat Containing 4 (“LRRC4”) family mimic molecule, wherein the LRRC4 family mimic molecule is capable of inhibiting, reducing, and/or dissociating an interaction between a Family with Sequence Similarity 19, Member A5 (“FAM19A5”) protein and a member of a LRRC4 protein family, wherein the LRRC4 family mimic molecule is a small molecule selected from:
Dependencies are inferred from the claim text.