Liposomes displaying a glycan ligand for cd33 and their use in the treatment of alzheimer's disease
AssigneeThe Governors of the University of Alberta
InventorsMatthew MACAULEY, Abhishek BATTACHERJEE, Arjun Singh BAINS, Gour DASKHAN
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Abstract
The present application provides a liposomal composition that multivalently displays a specific glycan ligand, or combination of specific glycan ligands, to specifically target CD33 on microglial cells. Multivalent engagement of CD33 with glycan ligands in the liposomal composition are useful in modulating microglial cell function, particularly as a therapeutic for the preventing, treating or delaying progression of Alzheimer's disease.
Claims19
A liposomal composition for inducing microglial phagocytosis, said composition comprising a liposome nanoparticle and a glycan ligand for CD33 displayed on the liposome nanoparticle.
A method for preventing, treating or delaying the progression of Alzheimer's disease in a subject, said method comprising administering to the subject a liposomal composition comprising a liposome nanoparticle and a glycan ligand for CD33 displayed on the liposome nanoparticle.
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Dependencies are inferred from the claim text.