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US 2024/0226372 A1Published application
Hydrophilic poly(thioketal) urethane scaffolds and methods of use thereof
AssigneeVanderbilt University
InventorsCraig L. Duvall, Prarthana Patil, Mukesh K Gupta, Joshua Tyler McCune, Richard d'Arcy
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Abstract
The presently-disclosed subject matter includes hydrophilic thioketal polymers and scaffolds formed therefrom.
Claims20
A hydrophilic thioketal polymer comprising a structure according to Formula I:
- wherein a comprises a thioketal;
- wherein C1 comprises a zwitterionic monomer;
- wherein C2 comprises poly(ethylene glycol) (PEG);
- wherein x comprises OH, NH2, SH, hydroxyalkyl, aminoalkyl, or thioalkyl;
- wherein Z comprises —C1—, —C2—, or —C1-a-C2—;
- wherein n is between 0 and 15;
- wherein m is between 0 and 15;
- and
- wherein if one of either n or m is 0 the other is at least 1.
6 more elements
A hydrophilic thioketal polymer comprising a structure according to Formula II:
- wherein A comprises a thioketal crosslinker;
- wherein b comprises carbamate or carbonate;
- wherein C comprises poly(ethylene glycol) (PEG);
- wherein x comprises OH, NH2, SH, hydroxyalkyl, aminoalkyl, or thioalkyl;
- and
- wherein n is between 1 and 10.
3 more elements
A hydrophilic thioketal polymer comprising a structure according to Formula III:
- wherein A comprises a thioketal crosslinker;
- wherein b comprises a 2° or 3° amide;
- wherein C1 comprises a poly(peptide);
- wherein C2 comprises a poly(peptoid);
- wherein x comprises OH, NH2, SH, hydroxyalkyl, aminoalkyl, or thioalkyl;
- wherein y is from about 0 to about 1;
- wherein z is from about 1 to about 0;
- and
- wherein n is between 1 and 15.
6 more elements
Dependencies are inferred from the claim text.