Loading patent…
AssigneesThe Catholic University of Korea Industry-Academic Cooperation Foundation, Seoul National University R&Db Foundation, Daegu Gyeongbuk Institute of Science and Technology
InventorsKiyuk CHANG, Daehee HWANG, Min-Sik KIM, Eunmin KIM, Eun Hye PARK, Chan Woo KIM
Estimating the term…
The present disclosure relates to the preparation of citrullinated vimentin antigen-specific immune tolerogenic dendritic cells and a composition for preventing or treating heart failure after myocardial infarction comprising the same. According to the present disclosure, it is confirmed that immune tolerogenic dendritic cells differentiated by treating immature dendritic cells with citrullinated vimentin regulate the expression of immune-related factors and have an excellent therapeutic effect on heart failure caused by myocardial infarction.
A preparation method of immune tolerogenic dendritic cells comprising culturing immature dendritic cells in a citrullinated vimentin-containing medium.
A method for inducing differentiation of immature dendritic cells into immune tolerogenic dendritic cells, comprising treating immature dendritic cells with citrullinated vimentin.
Dependencies are inferred from the claim text.