US 2024/0226001 A1 · Contact Lenses And Other Eye-Contacting Matrices Carrying Mitochondrially-Targeted Antioxidants

Abstract

The present inventor has discovered how to adsorb a mitochondrially targeted compound (MTC) of general formula I on contact lenses and other matrices prior to the application of lenses or other matrix on the eye surface. After such matrix is positioned on the eye, MTC is translocated from the lens into cornea cells of the eye providing cornea protective effect and thus reducing side effects of contact lens application.

Claims2

Dependent claims

A method of reducing corneal damage during contact lens use, the method comprising the steps of:

(a) providing a contact lens stored in a saline solution, the saline solution comprising one or more mitochondrially-targeted compounds (MTC) selected from the group consisting of
(b) removing the contact lens from the storage solution;
and
(c) placing the contact lens onto an eye of a subject in need thereof;
whereby corneal damage in the subject is reduced compared to placing a contact lens stored in a saline solution lacking said one or more MTC onto the subject's eye.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/142,017Filed 1 May 2023

Priority

26 Mar 2015

Published

11 Jul 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61K 9/0051
Eye, e.g. artificial tears: ocular inserts or implants
A61K 31/352
Having six-membered rings with one oxygen as the only ring hetero atom: condensed with carbocyclic rings, e.g. methantheline
A61K 31/36
Having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel: compounds containing methylenedioxyphenyl groups, e.g. sesamin
A61K 31/473
Quinolines; Isoquinolines: ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines

Contact Lenses And Other Eye-Contacting Matrices Carrying Mitochondrially-Targeted Antioxidants

Life of this patent

Contact Lenses And Other Eye-Contacting Matrices Carrying Mitochondrially-Targeted Antioxidants

Life of this patent

Abstract

Claims2