Cyclic peptide-n-acetylgalactosamine (galnac) conjugates for drug delivery to liver cells
AssigneeMicrobio (Shanghai) Co. Ltd.
InventorsYi-Chung CHANG, Hui-Yu CHEN, Chi-Fan YANG, Huai-Yi CHEN
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Abstract
A conjugate comprising a cyclic peptide scaffold and one or more N-acetylgalactosamine (GalNAc) moieties. The conjugate may further carry a diagnostic or therapeutic agent for use in delivering the agent to liver cells. In some embodiments, the cyclic peptide may have 4-10 amino acid residues. The GalNAc moieties can be covalently bound to the cyclic peptide scaffold via a first linker and the agent can be covalently bound to the cyclic peptide scaffold via a second linker.
Claims26
A conjugate, comprising a cyclic peptide scaffold and one or more N-acetylgalactosamine (GalNAc) moieties,
- wherein the cyclic peptide scaffold has 4-10, optionally 4-8, amino acid residues, which comprise Glu, Asp, Lys, Arg, or a combination thereof;
- and
- wherein each of the GalNAc moieties is covalently bound to the cyclic peptide scaffold via a first linker.
Dependencies are inferred from the claim text.