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US 2024/0210386 A1Published application
Purification of hla-specific antibodies
AssigneeOne Lambda
InventorsRui Pei, Quansheng Zhu, Tri Vu, David Philip Lowe
Life of this patent
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Abstract
Human leukocyte antigen (HLA) coated magnetic bead compositions, panels and methods of use thereof. A method of isolating HLA-specific antibodies including: contacting the composition of the disclosure with a liquid sample to specifically bind antibodies present in the liquid sample to HLA immobilized on magnetic beads; separating magnetic beads having antibodies bound to HLA of the magnetic beads from the liquid sample; and isolating the bound antibodies.
Claims26
A method comprising:
- a) contacting a composition comprising a magnetic bead having a human leukocyte antigen (HLA), or extracellular domain thereof, immobilized on the magnetic bead, with a liquid sample to specifically bind antibodies present in the liquid sample to HLA immobilized on magnetic beads;
- b) separating magnetic beads having antibodies bound to HLA of the magnetic beads from the liquid sample;
- and
- c) isolating the antibodies of b).
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A composition comprising:
- a magnetic bead having a human leukocyte antigen (HLA), or extracellular domain thereof, immobilized on the magnetic bead.
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Dependencies are inferred from the claim text.