Back to results
US 2024/0207381 A1Published application
Bihaptenized autologous vaccines and uses thereof
AssigneeBioVaxys Inc.
InventorDavid Berd
Life of this patent
Estimating the term…
Abstract
In some embodiments. methods of treating cervical cancer, including cervical cancers that are resistant to immune checkpoint inhibitor therapy. and cervical cancers that do not respond to immune checkpoint inhibitor therapy or have acquired resistance to immune checkpoint inhibitor therapy are disclosed.
Claims22
A method of treating cervical cancer in a human subject, the method comprising co-administering to the subject in need thereof one or more compositions comprising therapeutically effective amounts of:
- (i) at least one immune checkpoint inhibitor;
- and,
- (ii) an autologous bihaptenized vaccine.
A personalized diagnostic test kit, the kit comprising:
- (i) one or more single dose filled vial wherein the vial fill comprises bihaptenized autologous tumor cells in a pharmaceutically acceptable carrier;
- (ii) one or more single dose filled vials wherein the vial fill comprises a test negative control in a pharmaceutically acceptable carrier;
- (iii) written instructions;
- and
- (iv) a guide for scoring the test results.
2 more elements
A method of treating cervical cancer, the method comprising:
- (i) administering an effective amount of at least one immune checkpoint inhibitor;
- and,
- (ii) administering an effective amount of an autologous bihaptenized vaccine wherein the autologous bihaptenized vaccine is prepared by a process comprising the steps of:
- (a) washing a dissected cervical tumor fragment, wherein the fragment is at least about one cm in diameter;
- (b) dissociating the cervical tumor fragment into a suspension of cells;
- (c) irradiating the suspension of cells with gamma radiation;
- (d) dividing the irradiated suspension of cells into at least two approximately equal portions;
- (e) haptenizing a first portion with a first haptenization reagent and a second portion with second haptenization reagent;
- (f) fixing each portion;
- (g) combining the portions;
- and,
- (h) aliquoting cells comprising the product of step (g) into aliquots of about 6×106 to about 50×106 cell/mL.
9 more elements
Dependencies are inferred from the claim text.