Engineering of antigen-binding proteins

A system comprising:

• a processor;
• and
• a computer readable medium comprising instructions that, when executed by the processor, cause the processor to perform a method of identifying an antigen-binding protein comprising a pair of chains, the method comprising:
• receiving, by said processor, a query sequence comprising a first chain sequence, and
• identifying, by said processor, a corresponding chain sequence, thereby identifying an antigen-binding protein comprising the first chain sequence and corresponding chain sequence,
• wherein said identifying is performed by said processor providing the query sequence to a deep learning model configured to take as input a query first chain sequence and to produce as output at least one corresponding chain sequence, thereby identifying a corresponding chain sequence for the query sequence, wherein the deep learning model has been trained using training first and corresponding chain sequences from known chain pairs.

One or more computer readable media comprising instructions that, when executed by one or more processors, cause the one or more processors to perform a method of identifying an antigen-binding protein comprising a pair of chains, the method comprising:

• receiving, by said processor, training data comprising training first and corresponding sequences from known first and corresponding chain pairs;
• training, by said processor, a deep learning model to take as input a query first chain sequence and to produce as output at least one corresponding chain sequence, using the training data;
• receiving, by said processor, a query sequence comprising a first chain sequence, and
• identifying, by said processor, a corresponding chain sequence, thereby identifying an antigen-binding protein comprising the first chain sequence and corresponding chain sequence, wherein said identifying is performed by said processor providing the query sequence to the trained deep learning model configured to take as input a query first chain sequence and to produce as output at least one corresponding chain sequence, thereby identifying a corresponding chain sequence for the query sequence.