Spatial analysis of mitotic figures in histopathological images

A system, comprising:

• at least one data processor;
• and
• at least one memory storing instructions, which when executed by the at least one data processor, result in operations comprising:
• identifying, within an image of a biological sample, a plurality of mitotic figures associated with a tumor tissue present in the biological sample, each mitotic figure of the plurality of mitotic figures corresponding to a tumor cell that is undergoing mitosis;
• determining, based at least on the plurality of mitotic figures in the biological sample, a mitotic metric quantifying a spatial distribution of the plurality of mitotic figures within the biological sample;
• and
• determining, based at least on the mitotic metric, a tumor grade for the tumor tissue present in the biological sample.

A non-transitory computer readable medium storing instructions, which when executed by at least one data processor, result in operations comprising:

• identifying, within an image of a biological sample, a plurality of mitotic figures associated with a tumor tissue present in the biological sample, each mitotic figure of the plurality of mitotic figures corresponding to a tumor cell that is undergoing mitosis;
• determining, based at least on the plurality of mitotic figures in the biological sample, a mitotic metric quantifying a spatial distribution of the plurality of mitotic figures within the biological sample;
• and
• determining, based at least on the mitotic metric, a tumor grade for the tumor tissue present in the biological sample.