Method and kit for predicting preeclampsia
OwnerFlorian Herse, Louise Bjorkholt Andersen +2inventors
InventorsFlorian Herse, Louise Bjorkholt Andersen, Andreas Busjahn, Ralf Dechend
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Abstract
The invention pertains to a method for the prediction of preeclampsia in a pregnant female human subject until the end of gestational week 16 of pregnancy based on metabolites from a blood sample obtained from said subject. According to the invention, the method comprises the following steps: measuring the level of the following metabolites in the sample: 14,15-DHET, 13-HODE, 10,11-EDP, 21-HDHA, and 11,12-DHET, and concluding based on the measured level whether the subject is likely to develop preeclampsia.
Claims16
A method for the prediction of preeclampsia in a pregnant female human subject until the end of gestational week 16 of pregnancy based on metabolites from a blood sample obtained from said subject, comprising:
- measuring the level of the following metabolites in the sample:
- 14,15-DHET, 13-HODE, 10,11-EDP, 21-HDHA, and 11,12-DHET, and
- concluding based on the measured level whether the subject is likely to develop preeclampsia.
(canceled)
A kit for the prediction of preeclampsia in a female human subject based on metabolites obtained from a blood sample, comprising samples of the following metabolites:
- 14,15-DHET, 13-HODE, 10,11-EDP, 21-HDHA, and 11,12-DHET, in particular for use as a standard in mass spectrometry.
(canceled)
A method for preparing a metabolite profile that is indicative of the presence or absence of preeclampsia in a subject, comprising:
- isolating metabolites from a blood sample obtained from the subject, and
- measuring the level of the following metabolites in the sample:
- 14,15-DHET, 13-HODE, 10,11-EDP, 21-HDHA, and 11,12-DHET.
(canceled)
Dependencies are inferred from the claim text.