US 2024/0201205 A1 · METHOD FOR DETECTING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS

Method for detecting neurological diseases using supramolecule polymer therapeutics

AssigneeThe Regents of the University of California

InventorsStanley B. Prusiner, Nick A. Paras, Jay Conrad, Ny Sin, Sandeep Raikar, Mark Vander Wal, Jean-Marc M. Grandjean, Shigeo Yamanoi, Masahiro Inoue, Shimpei Hirano, Masatoshi Honzumi, Osamu Iwamoto, Koji Sasaki, Yamato Suzuki, Atsushi Tengeiji, Daniel R. Southworth, Darren Hutt, Jacob I. Ayers, Steven H. Olson, Cuong Quoc Ly, John West, Gregory E. Merz, Helene Viart

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Abstract

A method for detecting a neurological disease the method comprising isolating brain tissue from its natural environment, contacting the brain tissue with a labeled molecule which binds to multiple sites of stacked proteins associated with neurodegenerative disease, determining the binding of the labeled molecule; and thereby determining a neurodegenerative disease associated with the brain tissue.

Claims20

Dependent claims

A method of detecting a neurological disease, comprising:

contacting the brain tissue with a labeled molecule which binds multiple sites of stacked proteins associated with a neurological disease;
determining binding of the labeled molecule;
and
thereby determining a neurological disease associated with the brain tissue.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

18/468,639Filed 15 Sep 2023

Priority

15 Sep 2022

Published

20 Jun 2024

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Classification26 codes

G01N 33/6896
Related to diseases not provided for elsewhere: neurological disorders, e.g. Alzheimer's disease
A61K 31/4162
1,2-Diazoles: condensed with heterocyclic ring systems
A61K 31/4245
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: oxadiazoles
A61K 31/437
Ortho- or peri-condensed with heterocyclic ring systems: the heterocyclic ring system containing a five-membered ring having nitrogen as a ring…