Method of Tracking Maintenance of Immunological Tolerance
AssigneeCour Pharmaceuticals Development Company, Inc.
InventorsJohn Puisis, James Herrmann, Michael Boyne, Adam Elhofy, Joseph Podojil, Greta Wodarcyk
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Abstract
The present application relates, in general, to methods for tracking the induction of and long-term maintenance of antigen specific immune tolerance during administration of an antigen specific immune tolerizing therapy, such as a TIMP.
Claims46
A method for monitoring immune tolerance status of a subject undergoing immune tolerizing treatment for a disease or condition, the method comprising the steps of
- (a) obtaining one or more biological samples from the subject prior to administration of treatment and determining the immune tolerance status of the subject by assaying said biological sample(s),
- (b) obtaining one or more biological samples from the subject after administration of treatment and determining the immune tolerance status of the subject by assaying the biological sample(s), and
- (c) obtaining one or more biological samples from the subject at regular intervals after administration of treatment and determining the immune tolerance status of the subject by assaying the biological sample(s),
- (d) comparing the results from the assay of one or more biological samples in step (c) with the results of steps (a) and/or (b) to generate an immune tolerance signature, and
- (e) re-administering the tolerizing treatment if the immune tolerance signature indicates a weakening, and/or loss of immunological tolerance.
The method of claim 21, wherein the immune tolerance status of the subject at Baseline is determined by comparing the results from the assay of one or more biological samples in Step (a) to the assay of samples obtained from a healthy subject.
Dependencies are inferred from the claim text.