Electrochemical analyte biosensors, associated compositions of matter, and methods for making and using same

An electrochemical analyte biosensor configured to detect an analyte, the electrochemical analyte biosensor comprising:

• a first continuous network comprising a microporous polymer having a plurality of interconnected pores;
• a second substantially continuous network comprising a metal, the second substantially continuous network at least partially interpenetrating the first continuous network;
• and
• at least one immobilized bioreceptor region adjacent to the second substantially continuous network.

A method of manufacturing an electrochemical analyte biosensor configured to detect an analyte, the method comprising:

• providing a first continuous network comprising a microporous polymer having a plurality of interconnected pores;
• coating a metal onto the microporous polymer of the first continuous network to form a second substantially continuous network that at least partially interpenetrates the first continuous network;
• or
• imbibing the microporous polymer of the first continuous network with a metallic precursor;
• reducing the metallic precursor to a metal to form a second substantially continuous network that at least partially interpenetrates the first continuous network
• and
• positioning at least one immobilized bioreceptor region adjacent to the second substantially continuous network.