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US 2024/0201089 A1Published application
Optical real-time biosensor
AssigneesCZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior University
InventorsAmani Hariri, Constantin Dory, Alyssa Cartwright, Jelena Vuckovic, Hyongsok Tom Soh
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Abstract
The disclosure provides an optical probe comprising an optical waveguide attached to a molecular switch that produces an altered optical signal upon binding a target molecule. The disclosure also provides an optical sensor system comprising an optical probe, a light source configured to emit the excitation light to be coupled into the optical waveguide of the optical probe; and a detector.
Claims28
An optical probe comprising:
- an optical waveguide having a first end and a second end, the first end configured to receive excitation light to be propagated through the optical waveguide and to be emitted from the second end or a middle region into a surrounding medium;
- one or more molecular switches attached to a facet or a sidewall of the second end or the middle region of the optical waveguide, wherein the molecular switches are configured to change conformation upon binding to a corresponding target molecule;
- and
- one or more optical reporters, the optical reporters attached to a respective molecular switch and configured, when exposed to the excitation light, to produce an optical signal that changes upon binding of the respective molecular switch to the corresponding target molecule in the surrounding medium, wherein the optical signal is coupled back into the optical waveguide and propagated through the optical waveguide to be emitted from the first end or second end.
1 more element
Dependencies are inferred from the claim text.