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US 2024/0201088 A1Published application
Optical systems for nucleic acid sequencing and methods thereof
AssigneeElement Biosciences, Inc.
InventorsArash GHORBANI, Russell HUDYMA, John BAILEY, Michael PREVITE
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Abstract
Fluorescence imaging system designs are described that provide larger fields-of-view, increased spatial resolution, improved modulation transfer and image quality, higher spatial sampling frequency, faster transitions between image capture when repositioning the fields-of-view, improved imaging system duty cycle and a more compact system, and thus enable higher throughput image acquisition and analysis for genomics and other imaging applications at a lower cost.
Claims20
A method, comprising:
- (a) providing a system comprising:
- (i) a flow cell comprising a sample,
- (ii) a light source,
- (iii) a detector comprising a plurality of pixels, and
- (iv) a pixel shifter disposed in an optical path from the flow cell to the detector;
- (b) illuminating the sample using the light source, wherein the illuminating generates a signal light corresponding to an identity of a portion of the sample;
- (c) shifting the signal light across the plurality of pixels using the pixel shifter;
- and
- (d) detecting, using the plurality of pixels, the signal light from the sample to generate data related to the identity of the portion of the sample.
6 more elements
Dependencies are inferred from the claim text.