Analysis of effluent
AssigneeDroplet Biosciences, Inc.
InventorWendy Winckler Adamovich
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Abstract
The invention provides methods of detecting, or predicting the aggressiveness of, a tumor by measuring cancer biomarkers in surgical drain fluid that may be collected from the site of a surgery such as a tumor resection or lymphadenectomy. Surgical drain fluid (SDF), and the lymph component of SDF in particular, contains biomarkers that demonstrably correlate to future cancer outcomes and that are thus predictive of the growth or aggressiveness of a tumor.
Claims26
A method of predicting cancer recurrence, the method comprising:
- obtaining lymphatic fluid from a site proximal to a tumor;
- measuring a level of a predetermined protein in the lymphatic fluid;
- and
- predicting recurrence of the cancer on the basis of the measured level.
A method of therapeutic selection, the method comprising:
- obtaining lymphatic fluid from a site proximal to a tumor in a subject;
- measuring a level of a predetermined protein in the lymphatic fluid;
- and
- selecting a treatment for the subject on the basis of the measured level.
The method of 14, wherein the protein is a pro-inflammatory cytokine, and the measured level is used to select an adjuvant therapy.
A method of predicting a cancer therapy outcome, the method comprising:
- obtaining lymphatic fluid from a site proximal to a tumor in a subject who has been treated for cancer by a neoadjuvant therapy and surgery;
- measuring a level of a predetermined protein in the lymphatic fluid;
- and
- determining a pharmacodynamic effect of the neoadjuvant therapy on the basis of the measured level.
Dependencies are inferred from the claim text.