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US 2024/0200146 A1Published application
Diagnostic and therapeutic methods for cancer
AssigneeGenentech, Inc.
InventorsChristiaan Nicolaas Klijn, Shiva Malek, Ivana Yen
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AssigneeGenentech, Inc.
InventorsChristiaan Nicolaas Klijn, Shiva Malek, Ivana Yen
Estimating the term…
The present invention provides diagnostic and therapeutic methods and compositions for cancer. The invention provides methods of determining whether an individual having a cancer is likely to respond to treatment comprising a pan-RAF dimer inhibitor and a MEK or PI3K inhibitor, methods of predicting responsiveness of an individual having a cancer to treatment comprising a pan-RAF dimer inhibitor and a MEK or PI3K inhibitor, methods of selecting a therapy for an individual having a cancer, and methods of treating an individual having cancer based on the presence of a biomarker of the invention (e.g., a KRAS activating mutation, e.g., a KRAS-G13D mutation, or an NRAS activating mutation).
A method of treating an individual having a cancer, the method comprising:
A method of treating an individual having a cancer, the method comprising administering to the individual a therapeutically effective amount of a pan-RAF dimer inhibitor and a MEK inhibitor, wherein prior to treatment a sample from the individual has been screened for an NRAS activating mutation and the presence of an NRAS activating mutation in the sample has been determined.
Dependencies are inferred from the claim text.