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US 2024/0200133 A1Published application
Optical systems for nucleic acid sequencing and methods thereof
AssigneeElement Biosciences, Inc.
InventorsArash GHORBANI, Russell HUDYMA, John BAILEY, Michael PREVITE
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Abstract
Fluorescence imaging system designs are described that provide larger fields-of-view, increased spatial resolution, improved modulation transfer and image quality, higher spatial sampling frequency, faster transitions between image capture when repositioning the fields-of-view, improved imaging system duty cycle and a more compact system, and thus enable higher throughput image acquisition and analysis for genomics and other imaging applications at a lower cost.
Claims20
A method of imaging a sample, said method comprising:
- (a) providing an optical system, wherein the optical system comprises:
- (1) a light source that illuminates said sample with a first light;
- (2) a sensor that obtains an image of said sample while said sample is illuminated by said first light from said light source;
- and
- (3) a focusing element assembly disposed along an optical path from said light source to said sensor, wherein said focusing element assembly comprises (i) a first focusing element, and (ii) a second focusing element, wherein said first focusing element moves relative to said second focusing element without removal of said first focusing element from said optical path;
- (b) illuminating said sample with said first light from said light source;
- (c) focusing a second light emitted from said sample with said focusing element assembly;
- and
- (d) receiving said second light from (c) and obtaining one or more images of said sample by said sensor.
6 more elements
Dependencies are inferred from the claim text.