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US 2024/0200080 A1Published application
Diagnostic device for local intravenous biomarker measurements and methods of use thereof
AssigneeCook Medical Technologies LLC
InventorsGrainne Leonard, Jennifer O'Malley, Diarmuid McGee, Criostoir O Bhealtun, David Slattery, Kevin Chmura
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Abstract
A device including a needle configured to measure portal pressure in a vein of a mammal and provide an indication of a measurement a diagnostic biomarker in a sample drawn from the vein before removing the needle is provided. Methods of providing medical data about a patient by use of a device are further provided.
Claims20
A medical device, comprising:
- a tubular body defining a lumen extending longitudinally therethrough, the tubular body defining a longitudinal axis, the tubular body comprising:
- a needle comprising the lumen extending longitudinally therethrough;
- a handle proximal to the needle;
- a stopcock proximal to the handle, the stopcock configured to close or open the lumen to flow of a sample proximal to the stopcock;
- a connecting tube proximal to the stopcock, the connecting tube comprising the lumen;
- a pressure transducer proximal to the connecting tube;
- and
- a syringe proximal to the pressure transducer;
- and
- a sample measurement device attached to the handle or to the needle near a distal tip of the needle;
- wherein the device is configured to provide a measurement of portal pressure in a vein of a mammal and an indication of a measurement of a diagnostic biomarker in a sample from the vein before the needle is removed from the vein.
8 more elements
A method of providing medical data about a mammal, comprising:
- inserting a needle of a medical device into a vein of the mammal;
- measuring a portal pressure in the vein;
- collecting a sample from the vein;
- measuring a diagnostic biomarker within the sample;
- and
- removing the needle from the vein;
- wherein an indication of a measurement of the diagnostic biomarker is provided prior to the removing.
4 more elements
A method of providing medical data about a mammal, comprising:
- inserting a needle of a device into a vein of the mammal, the device further comprising a digital microfluidic biochip;
- measuring a portal pressure in the vein;
- collecting a sample from the vein;
- measuring a diagnostic biomarker within the sample;
- and
- removing the device from the vein;
- wherein an indication of a measurement of the diagnostic biomarker is provided prior to the removing;
- and
- wherein the diagnostic biomarker comprises:
- a white blood cell count, a red blood cell count, a platelet count, a hematocrit, one or more of red blood cell indices, apolipoprotein F, lipopolysaccharide-binding protein, ficolin-2, apolipoprotein D, kininogen-1, apolipoprotein M, thrombospondin-1, IgG F C-binding protein, cystatin-C, alpha-1-acid glycoprotein 2, leucine-rich alpha-2-glycoprotein, circulating tumor cells, exosomes, or combinations thereof.
7 more elements
Dependencies are inferred from the claim text.