Stearoyl-coa desaturase 5 (scd5) irna agent compositions and methods of use thereof
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsLAN THI HOANG DANG, JAMES D. MCININCH, ADAM CASTORENO
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Abstract
The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a Stearoyl-CoA Desaturase 5 (SCD5) gene, as well as methods of inhibiting expression of an SCD5 gene and methods of treating subjects having an SCD5-associated disease or disorder, e.g., Parkinson's disease, using such dsRNAi agents and compositions.
Claims104
A double stranded ribonucleic acid (dsRNA) agent for inhibiting expression of SCD5, wherein the dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region,
- wherein the sense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:
- 1 and the antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:
- 2.
A double stranded ribonucleic acid (dsRNA) agent for inhibiting expression of SCD5, wherein the dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region,
- wherein the antisense strand comprises a region of complementarity to an mRNA encoding SCD5, and wherein the region of complementarity comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of SEQ ID NO:2.
A double stranded ribonucleic acid (dsRNA) agent for inhibiting expression of SCD5, wherein the dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region,
- wherein the antisense strand comprises a region of complementarity to an mRNA encoding SCD5, and wherein the region of complementarity comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from any one of the antisense nucleotide sequences in Tables 2 or 3.
Dependencies are inferred from the claim text.