Transformed cell lines expressing il24-stat3 and methods for screening agents for treating by targeting il24-stat3 signaling pathway using the same
AssigneeUIF (University Industry Foundation), Yonsei University
InventorsJinu LEE, Sei Mee Yoon
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to a transformed cell line expressing the IL24-STAT3 signaling system and a method for screening a substance targeting the IL24-STAT3 signaling pathway using the same. The present disclosure provides a method for screening an inhibitor involved in the -STAT3 signaling by expressing an IL20 receptor complex binding specifically to IL24 in the presence of IL24 and activating the STAT3 signaling process.
Claims8
A transformed HeLa cell for analyzing change in the IL24-STAT3 signaling pathway, which expresses IL24 receptors IL22RA1 (interleukin 22 receptor subunit alpha 1), IL20RB (interleukin 20 receptor subunit beta) and STAT3 (signal transducer and activator of transcription 3) genes.
Dependencies are inferred from the claim text.