Engineered hla molecules useful for t cell and nk cell activation and expansion

Abstract

In some aspects, the present invention involves chimeric recombinant HLA proteins that are derived from HLA-E proteins and comprise a leader peptide from an HLA-A, HLA-B, HLA-C or HLA-G protein. In some aspects, the present invention also involves nucleic acid molecules encoding such recombinant HLA proteins, vectors comprising such nucleic acid molecules, host cells comprising such recombinant HLA proteins, and various related compositions. In some aspects, the present invention also involves methods of use of such recombinant HLA proteins, nucleic acid molecules, vectors, host cells and compositions.

Dependencies are inferred from the claim text.