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US 2024/0200007 A1Published application
Combinatorial fluid switch for use in automated cell engineering systems
OwnerPeter SZARAZ, Nuala TRAINORinventors
Life of this patent
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Abstract
The present disclosure provides combinatorial fluid switches that allow for the selection of a single fluid flow-path, while controlling multiple flow-paths. The combinatorial fluid switches can be used in various biological systems and processes, included automated cell engineering systems.
Claims44
A combinatorial fluid switch for controlling fluid flow through a plurality of fluid flow-paths, comprising:
- (a) a plurality of fluid inputs;
- (b) a first two-position valve having individual fluid flow-paths, through which fluids from the plurality of fluid inputs are guided;
- (c) a second two-position valve having individual fluid flow-paths, through which fluids from the plurality of fluid inputs are guided;
- and
- (d) a plurality of fluid outputs,
- wherein the combinatorial fluid switch is configured to allow:
- fluid flow from a first fluid input to a first fluid output when the first two-position valve is in an open position and the second two-position valve is in an open position;
- fluid flow from a second fluid input to a second fluid output when the first two-position valve is in a closed position and the second two-position valve is in an open position;
- fluid flow from a third fluid input to a third fluid output when the first two-position valve is in an open position and the second two-position valve is in a closed position;
- and
- fluid flow from a fourth fluid input to a fourth fluid output when the first two-position valve is in a closed position and the second two-position valve is in a closed position.
8 more elements
A combinatorial fluid switch for controlling fluid flow through at least four fluid flow-paths, comprising:
- (a) a first, a second, a third and a fourth fluid inputs;
- (b) a first two-position valve having four fluid flow-paths, through which fluids from the first, second, third and fourth fluid inputs are guided;
- (c) a second two-position valve having four fluid flow-paths, through which fluids from the first, second, third and fourth fluid inputs are guided;
- and
- (d) a first, a second, a third and a fourth fluid outputs, wherein the combinatorial fluid switch is configured to allow:
- fluid flow from the first fluid input to the first fluid output when the first two-position valve is in an open position and the second two-position valve is in an open position;
- fluid flow from the second fluid input to the second fluid output when the first two-position valve is in a closed position and the second two-position valve is in an open position;
- fluid flow from the third fluid input to the third fluid output when the first two-position valve is in an open position and the second two-position valve is in a closed position;
- and
- fluid flow from the fourth fluid input to the fourth fluid output when the first two-position valve is in a closed position and the second two-position valve is in a closed position.
7 more elements
A system for controlling fluid flow through at least sixteen fluid flow-paths, comprising:
- (a) a first combinatorial fluid switch comprising:
- i. a first, a second, a third and a fourth fluid inputs;
- ii. a first two-position valve having four fluid flow-paths, through which fluids from the first, second, third and fourth fluid inputs are guided;
- iii. a second two-position valve having four fluid flow-paths, through which fluids from the first, second, third and fourth fluid inputs are guided;
- and
- iv. a first, a second, a third and a fourth fluid outputs,
- wherein the first combinatorial fluid switch is configured to allow:
- fluid flow from the first fluid input to the first fluid output when the first two-position valve is in an open position and the second two-position valve is in an open position;
- fluid flow from the second fluid input to the second fluid output when the first two-position valve is in a closed position and the second two-position valve is in an open position;
- fluid flow from the third fluid input to the third fluid output when the first two-position valve is in an open position and the second two-position valve is in a closed position;
- and
- fluid flow from the fourth fluid input to the fourth fluid output when the first two-position valve is in a closed position and the second two-position valve is in a closed position;
- and
- (b) a second combinatorial fluid switch fluidly connected to the first combinatorial fluid switch, the second combinatorial fluid switch comprising:
- i. a fifth, a sixth, a seventh and an eighth fluid inputs;
- ii. a third two-position valve having four fluid flow-paths, through which fluids from the fifth, sixth, seventh and eighth fluid inputs are guided;
- iii. a fourth two-position valve having four fluid flow-paths, through which fluids from the fifth, sixth, seventh and eighth fluid inputs are guided;
- and
- iv. a fifth, a sixth, a seventh and an eighth fluid outputs,
- wherein the second combinatorial fluid switch configured to allow:
- fluid flow from the fifth fluid input to the fifth fluid output when the third two-position valve is in an open position and the fourth two-position valve is in an open position;
- fluid flow from the sixth fluid input to the sixth fluid output when the third two-position valve is in a closed position and the third two-position valve is in an open position;
- fluid flow from the seventh fluid input to the seventh fluid output when the third two-position valve is in an open position and the fourth two-position valve is in a closed position;
- and
- fluid flow from the eighth fluid input to the eighth fluid output when the third two-position valve is in a closed position and the fourth two-position valve is in a closed position.
22 more elements
A system for controlling fluid flow through at least sixteen fluid flow-paths, comprising:
- (a) a plurality of combinatorial fluid switches, each combinatorial fluid switch comprising:
- i. a first, a second, a third and a fourth fluid inputs;
- ii. a first two-position valve having four fluid flow-paths, through which fluids from the first, second, third and fourth fluid inputs are guided;
- iii. a second two-position valve having four fluid flow-paths, through which fluids from the first, second, third and fourth fluid inputs are guided;
- and
- iv. a first, a second, a third and a fourth fluid outputs,
- wherein the first combinatorial fluid switch is configured to allow:
- fluid flow from the first fluid input to the first fluid output when the first two-position valve is in an open position and the second two-position valve is in an open position;
- fluid flow from the second fluid input to the second fluid output when the first two-position valve is in a closed position and the second two-position valve is in an open position;
- fluid flow from the third fluid input to the third fluid output when the first two-position valve is in an open position and the second two-position valve is in a closed position;
- and
- fluid flow from the fourth fluid input to the fourth fluid output when the first two-position valve is in a closed position and the second two-position valve is in a closed position.
9 more elements
A combinatorial fluid switch, comprising:
- (a) a housing having two opposing sides, each side having four openings passing therethrough;
- and
- (b) two, two-position valves disposed within the housing, each valve having four openings passing therethrough,
- wherein the openings in the sides and the openings in the two-position valves are configured to receive tubing therethrough, so as to create four flow-paths within the combinatorial fluid switch, and
- wherein the two-position valves are moveable within the housing to allow fluid flow through only one flow-path at a time.
2 more elements
A combinatorial fluid switch, comprising:
- (a) a support base comprising two raised portions and two recessed portions, the two raised portions comprising a plurality of partitions extending above the support base configured to allow tubing to pass therethrough so as to create four fluid flow-paths, the two recessed portions each comprising four stationary compression members extending above the support base;
- (b) two, two-position valves having openings to allow the stationary compression members to pass through, the valves further comprising four movable compression members configured to compress against a complementary, stationary compression member on the support base so as to constrict a tubing between the movable compression member and the complementary, stationary compression member,
- wherein the two-position valves are configured to slide along the support base and allow fluid flow through only one flow-path at a time.
A combinatorial fluid switch, comprising:
- (a) at least three, stationary compression members;
- (b) a first two-position valve having two movable compression members integrated into the valve;
- and
- (c) a second two-position valve having three movable compression members integrated into the valve,
- wherein the movable compression members of the first and second two-position valves are configured to compress against a complementary, stationary compression member so as to constrict a tubing between the movable compression member and the complementary, stational compression member,
- wherein the two-position valves are configured to slide and allow fluid flow through one flow-path at a time.
3 more elements
A combinatorial fluid switch for controlling fluid flow through a plurality of fluid flow-paths, comprising:
- (a) a plurality of fluid inputs;
- (b) a first control valve, through which fluids from the plurality of fluid inputs are guided;
- (c) a second control valve having individual fluid flow-paths, through which fluids from the plurality of fluid inputs are guided;
- and
- (d) a plurality of fluid outputs,
- wherein the combinatorial fluid switch is configured to allow fluid flow through a designated combination of fluid inputs and fluid outputs.
3 more elements
A method for controlling fluid flow within a closed, cell engineering system, comprising:
- (a) providing a plurality of fluid inputs;
- (b) providing a plurality of fluid outputs;
- (c) providing a plurality of flow-paths connecting the fluid inputs to the fluid outputs;
- (d) providing a plurality of valves controlling the flow within the flow-paths, thereby controlling the direction, speed, duration and/or interval of fluid flow within the flow-paths.
1 more element
Dependencies are inferred from the claim text.