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US 2024/0199763 A1Published application
Conformation switching nanostructures
AssigneeTechnische Universität München
InventorsWouter ENGELEN, Christian SIGL, Hendrik DIETZ
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AssigneeTechnische Universität München
InventorsWouter ENGELEN, Christian SIGL, Hendrik DIETZ
Estimating the term…
The present invention relates to conditionally switchable nanostructures, and systems comprising the same. In particular, the present invention pertains to a method for linking the identification of at least one molecule to a conformational reconfiguration of a nanostructure. The invention is further based on the finding that coupling molecules, such as antibodies or antigen binding fragments, can stabilize subunit interactions of nanostructures at otherwise unfavourable conditions. Additionally, the present invention also relates to a system comprising the nanostructures of this invention as well as methods for utilizing the nanostructures or the system of this invention. Finally, substances and/or compositions comprising at least one or a plurality of nanostructures for use as a medicament, or for use in a diagnostic method, are also provided.
A nanostructure comprising at least two coupling sites, wherein said at least two coupling sites can bind to at least one coupling molecule, and wherein said at least two coupling sites are configured to be a coupling site set.
The nanostructure according to claim 2, wherein the nanostructure comprises at least one first entity and at least one second entity, wherein each of the at least one first entity and the at least one second entity comprises at least one coupling site of at least one coupling site set.
Dependencies are inferred from the claim text.