Bispecific antibodies targeting nkp46 and cd38 and methods of use thereof

A bispecific antibody that specifically binds NKp46 and CD38, comprising:

• i) a first heavy chain comprising
• a heavy chain complementarity determining region 1 (CDRH1) comprising an amino acid sequence of SEQ ID NO:
• 17;
• a heavy chain complementarity determining region 2 (CDRH2) comprising an amino acid sequence of SEQ ID NO:
• 18;
• and
• a heavy chain complementarity determining region 3 (CDRH3) comprising an amino acid sequence of SEQ ID NO:
• 19;
• ii) a first light chain comprising
• a light chain complementarity determining region 1 (CDRL1) comprising an amino acid sequence of SEQ ID NO:
• 20;
• a light chain complementarity determining region 2 (CDRL2) comprising an amino acid sequence of SEQ ID NO:
• 21;
• and
• a light chain complementarity determining region 3 (CDRL3) comprising an amino acid sequence of SEQ ID NO:
• 22;
• iii) a second heavy chain comprising
• a CDRH1 comprising an amino acid sequence of SEQ ID NO:
• 32;
• a CDRH2 comprising an amino acid sequence of SEQ ID NO:
• 33;
• and
• a CDRH3 comprising an amino acid sequence of SEQ ID NO:
• 34;
• and
• iv) a second light chain comprising
• a CDRL1 comprising an amino acid sequence of SEQ ID NO:
• 35;
• a CDRL2 comprising an amino acid sequence of SEQ ID NO:
• 36;
• and
• a CDRL3 comprising an amino acid sequence of SEQ ID NO:
• 37;
• and
• wherein the bispecific antibody comprises a first antigen binding region comprising i) and ii) that specifically binds to NKp46 and a second antigen binding region comprising iii) and iv) that specifically binds to CD38.