Pharmaceutical Composition

Abstract

The present invention provides a pharmaceutical composition comprising (a) a triblock copolymer having the formula: Av-Bw-Ax wherein A is a polyester, B is polyethylene glycol, v and x are the number of repeat units ranging from 1 to 3,000 and w is the number of repeat units ranging from 3 to 300 and v=x or v≠x in an amount of from about 3 to 25 w/w % of the total composition; (b) a diblock copolymer having the formula: Cy-Az Wherein A is a polyester, C is an end-capped polyethylene glycol and y and z are the number of repeat units with y ranging from 2 to 250 and z ranging from 1 to 3,000 in an amount of from about 3 to 35 w/w % of the total composition; (c) a therapeutic protein which is an Interleukin-1 antagonist in an amount of from about 0.5 to 25 w/w % of the total composition; (d) optionally one or more stabilizer compounds in an amount of from about 0.25 to 15 w/w % of the total composition; and (e) organic solvent in an amount of from about 50 to 80 w/w % of the total composition.

Dependencies are inferred from the claim text.