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US 2024/0199738 A1Published application
Monoclonal antibodies and conjugates against prostaglandin f2 receptor inhibitor and uses thereof
AssigneeA&G Pharmaceutical, Inc.
InventorGinette Serrero
Life of this patent
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Abstract
The present disclosure provides a novel antibody, antigen binding fragment thereof, or an antibody conjugate thereof, useful in methods for treatment or diagnosis of conditions characterized by the expression of PTGFRN. The antibodies or antigen binding fragments thereof may also be used in imaging or detecting cells that express PTGFRN.
Claims10
1-49. (canceled)
A conjugate comprising an antibody and a functional moiety joined by a linker, the antibody being an isolated antibody or antigen binding fragment thereof that specifically binds to prostaglandin F2 receptor inhibitory (PTGFRN), comprising:
- a) a heavy chain variable region comprising the CDR sequences SEQ ID NOs:
- 5, 6 and 7 and a light chain variable region comprising CDR sequences SEQ ID NOs:
- 8, 9 and 10;
- b) a heavy chain variable region comprising the CDR sequences SEQ ID NOs:
- 11, 12 and 13 and a light chain variable region comprising CDR sequences SEQ ID NOs:
- 20, 21 and 22;
- or,
- c) a heavy chain variable region comprising the CDR sequences SEQ ID NOs:35, 36 and 37 and a light chain variable region comprising CDR sequences SEQ ID NOs:
- 38, 39 and 40.
6 more elements
Dependencies are inferred from the claim text.