Back to results
US 2024/0199735 A1Published application
Microfibrillar-Associated Protein 5 (MFAP5)-Targeting Monoclonal Antibodies and Methods for Use in Treating Cancer
AssigneesThe Methodist Hospital, Board of Regents, The University of Texas System
InventorsStephen T.C. WONG, Jianting SHENG, Samuel C. MOK, Cecilia S. LEUNG, Tsz-Lun YEUNG
Life of this patent
Estimating the term…
Abstract
Disclosed are antibody compositions and methods for treatment mammalian cancers. Also disclosed are methods for use of the disclosed MFAP5-specific monoclonal antibodies and antigen-binding-fragments thereof, in the treatment, prophylaxis, and/or the amelioration of one or more symptoms of mammalian cancer, including human ovarian and pancreatic cancers, in particular.
Claims30
1-28. (canceled)
A isolated antibody or an antigen-binding fragment thereof, comprising:
- (i) a Variable Heavy Chain (VH) domain comprising a polypeptide sequence that is at least 95% identical to SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, or SEQ ID NO:13;
- and
- (ii) a Variable Light Chain (VL) domain comprising a polypeptide sequence that is at least 95% identical to SEQ ID NO:14 or SEQ ID NO:15.
Dependencies are inferred from the claim text.